The Binding of Isaac Repentance Unlocks
A progression roadmap from Mom to Dead God covering floors, endings, completion marks, items, and challenges.
What are Unlocks?
A prioritized unlock order for The Binding of Isaac: Repentance that opens the strongest items, characters, and alternate paths before low-impact goals.
Why follow an unlock order?
Improve the Pool
Unlock high-impact items early so future runs get stronger
Open Routes
Reach alternate floors, Mother, and The Beast through key milestones
Reach Dead God
Collect every Hard Mode, Greedier, and Tainted completion mark
Featured & Essential
The Binding of Isaac Repentance Achievements: Unlock Guide
Discover the optimal progression route to unlock all achievements in The Binding of Isaac: Repentance, including tips for Dead God.
the binding of isaac repentance dead god: Full Unlock Roadmap
Master the journey to the binding of isaac repentance dead god achievement. Learn the fastest completion mark routes, S-tier item synergies, and character strategies.
All Unlocks
The Binding of Isaac Repentance How to Unlock All Characters: 2026 Guide
Master the Binding of Isaac Repentance how to unlock all characters with our step-by-step roadmap for all 34 normal and Tainted variants.
the binding of isaac repentance item unlocks: Progression Guide
Master the Binding of Isaac Repentance item unlocks with our 2026 guide. Learn the best progression route, character rewards, and priority challenges.
The Binding of Isaac Repentance Tainted Unlocks: Tier List
Optimize your runs with our 2026 tier list for the binding of isaac repentance tainted unlocks. Learn how to unlock every Tainted character and item.
The Binding of Isaac Repentance Unlock Guide: Progression Route
Master the optimal progression route in Repentance. Unlock characters, alternate paths, and S-tier items with this step-by-step roadmap.